My next post was going to be about how I am enjoying this pregnancy (a lot, honestly, I promise!) despite my worries. But then I got the call from RE's office about the latest P4/E2 results, so enjoyment is once again taking a back seat to concern.
The weaning had been going well. For some reason, I haven't ever been nervous about the E2, only the P4. They've been weaning me very slowly. I was on 3 progesterone suppositories per day and 1cc of PIO per day. We started by going to 2 suppositories a day, still doing the 1cc every day. Tested a few days later, P4 was at 35. Then went to 2 supps and 1/2 cc every day. After a few days, P4 was at 39. I was excited - I thought this meant my placenta was taking over.
Then we dropped down to 1 supp a day and 1/2 cc every day. P4 went back to 35, but the nurse assured me that it fluctuates, so I still didn't worry about it. (That was Friday.) Then we went to 1 supp a day and 1/2 cc every other day.
Today's test result showed P4 at 19.7.
The nurse said RE wants to see it above 20, but from what I'm reading online, the typical P4 level at 12 weeks (today is 11w5d) is around 33. And my P4 would be even lower than 19.7 if I wasn't on the supp and 1/2 cc.
For some reason, I've just always been nervous about my body's ability to produce an adequate amount of progesterone without supplementation, so I asked the peri about it during our first appointment. I've read a lot of information online about supplementation during the 2nd and 3rd trimesters being necessary for some women and that it's totally safe. However, it also sounds like there are a lot of OBs/peri's who don't believe in it.
I think my peri falls into the second camp - she basically said she doesn't use it after the first trimester and that if the placenta isn't producing an adequate amount, that's a sign of a bigger problem with the placenta that would likely jeopardize the pregnancy. But it seems like there are a lot of women out there who had second trimester losses, and then when they were on progesterone in subsequent pregnancies (including during the second and third trimester), they went on to have healthy babies. So obviously their placenta didn't completely fail them...
The plan is to continue with the 1 supp and 1/2 cc every other day for now, and then re-test P4 on Friday to see if it's increasing. If not, I'm going to insist on going back up to a higher dosage. I asked the nurse what happens if it stays low, and she said she'd have to talk with RE.
On the other hand, it seems my E2 is perfectly fine. I'm down to 2 patches every other day and no estrace at all, and my level was just under 1,200 today. The nurse said that level was totally normal, and it's up slightly from just under 1,100 when I first started weaning. I couldn't find much info online regarding what normal E2 levels should be at this point, but the couple of charts I did see seemed to indicate it should be closer to 2,000 at 12 weeks. So not sure what to think on that one either.
To top it all off, yesterday on and off and for most of today, I've had a resting heart rate of 100-120 bpm (tachycardia). It finally seems to be easing up this evening. I'm not sure it's pregnancy-related, though. That used to happen a lot when I was in a hyperthyroid state before my thyroidectomy, so I have assumed it was thyroid-related, especially because it didn't happen for quite a while after the surgery.
But then it started happening again last summer and really started to become annoying last fall, so I assumed my thyroid meds were too high and asked my family doc to lower my dosages. If you recall some of my posts from spring, that didn't work out well - I wound up in acute kidney failure (resolved by increasing my dosages back to what they were), and the tachycardia went away on its own.
Peri just checked my thyroid levels last week and free T3 and T4 were a little lower than mine normally are (but still within the normal range) and T4 was up to 4.45 (it had been 1.something a couple weeks before transfer), so she's increasing my Syn.throid from 125 to 138, but I haven't started the 138 yet.
It looks like we'll have lots to discuss during my appointment on Friday...
Broken Things
8 years ago



